Worldwide, a number of research groups are functioning towards effective treatment of colon cancer using chemotherapeutic agents. Nonsteroidal anti-inflammatory drugs are among the most potent agents discovered for the inhibition of cancer. In spite of the approval of celecoxib for adjuvant therapy in patients with familial adenomatous polyposis and precancerous disease of colon, associations of larger intensity of side effects limit its usage in cancer therapy. Combination therapy provides advantages of reduction in dose and possible reduction in toxicity and acquired drug resistance. As a consequence, targeted drug delivery and targeted molecular therapy of single or combination of anticancer agents are necessary for efficient treatment of colon cancer with reduced toxicity. In our study, combination of celecoxib and AEE788 shows growth inhibition and apoptosis in HCT 15 cells. Further, nanocarrier mediated celecoxib delivery showed high entrapment efficiency, sustained release patterns, desirable hemocompatibility and enhanced cytotoxicity and apoptosis in vitro and in vivo.
This book on HIV counseling and testing (HCT) is an important resource for HIV prevention and care. The knowledge and acceptance of serostatus can facilitate behavioural change, enable access to strategies to reduce the risk of mother to child transmission of HIV, enable early access to care for HIV-related conditions, and help in making informed decisions about future pregnancies. This study was designed to find out the factors influencing uptake of Human Immuno-deficiency (HIV) counselling and testing (HCT) among pregnant women attending antenatal clinic in Sabon-Gari Comprehensive Health Centre, Zaria, Nigeria. A descriptive cross sectional survey was done. The fear of stigmatization is a factor militating against uptake of HCT. To improve the uptake of HCT services more innovative ethical and practical models of delivery should be developed and adopted. Improved awareness and education will reduce stigmatization of PLWHAS. This book is a must-read for all public health practitioners and maternal health care providers interested in working in Africa and in the tropics. It is also recommended for medical students and nurses who are seeking to broaden their knowledge on HCT.